Hepatitis E virus superinfection impairs long-term outcome in hospitalized patients with hepatitis B virus-related decompensated liver cirrhosisObservational Study Published on 2023-03-012023-06-09 Journal: Annals of hepatology [Category] B형 간염, E형 간염, [키워드] Co-infection decompensation Disease progression Mortality Viral hepatitis. [DOI] 10.1016/j.aohep.2022.100878 PMC 바로가기 [Article Type] Observational Study
Impact of Early SARS-CoV-2 Antiviral Therapy on Disease ProgressionArticle Published on 2022-12-272023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] Antiviral treatment COVID-19 Disease progression molnupiravir monoclonal antibody Nirmatrelvir/ritonavir Remdesivir SARS-CoV-2 vaccination. [DOI] 10.3390/v15010071 PMC 바로가기
The role of kidney injury biomarkers in COVID-19COVID-19에서 신장 손상 바이오마커의 역할Review Published on 2022-12-012022-09-11 Journal: Renal failure [Category] 바이오마커, [키워드] Acute kidney injury AKI Biomarker biomarker. Biomarkers clinical settings complex coronavirus coronavirus disease COVID-19 death demonstrated Diagnosis disease Disease progression early diagnosis global pandemic high mortality rate hospital IGFBP7 IL-18 IMPROVE independent risk factor Intervention kidney Kidney injury molecular molecular mechanism molecular mechanisms outbreak outcomes Patient patients with COVID-19 Research Sepsis suPAR unique [DOI] 10.1080/0886022X.2022.2107544 PMC 바로가기 [Article Type] Review
Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters시리아 골든 햄스터에서 SARS-CoV-2 Omicron BA.1(B.1.1.529) 변종 접종 후 폐 병변Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] animals B.1.1.529 B.1.617.2 characterized Clinical signs COVID-19 disease decrease Delta Disease progression disease severity evaluate Evidence evidence of golden hamster hamster hamsters histopathological Human Immune escape Immunity Infection inoculated intrinsic Kinetics lesion Mutation omicron Omicron BA.1 pathogenicity pathological changes pathology Pneumonia pre-existing immunity progression pulmonary re-challenge. reduced SARS-CoV-2 SARS-CoV-2 variant Syrian golden hamster the SARS-CoV-2 vaccination variant viral genome viral shedding viral spread virus [DOI] 10.1080/22221751.2022.2095932 PMC 바로가기 [Article Type] Article
Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic controlResearch article Published on 2022-12-012022-10-05 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 analysed antagonistic autophagy caused Cell cellular metabolism cellular processe Course COVID-19 death Disease progression enzyme Epigenetic epigenetics example expression profile function genes encoding Genome Host host cell IL-6 Infection investigated Laboratory Lipid mechanism membrane metabolic activity metabolic pathway methionine pathogen invasion patients Perspective progression rDNA Regulation replication mechanism ribosome S-adenosylmethionine SARS-CoV-2 sera social isolation the disease the patient therapeutic therapy tissue viral loads virus virus particle virus replication [DOI] 10.1016/j.bbadis.2022.166527 [Article Type] Research article
Enhanced Label-Free Nanoplasmonic Cytokine Detection in SARS-CoV-2 Induced Inflammation Using Rationally Designed Peptide AptamerArticle Published on 2022-11-022022-11-15 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis Antibody-derived peptide aptamer (ADPA) applied aptamer Biomarker coronavirus COVID-19 patients cytokine detection Detection limit Disease progression disorders enhanced IL-6 immune pathway Immune status immunoassay immunoassays in vitro induced Inflammation inflammatory status information interleukin 6 (IL-6 Interluekin-6 (IL-6) Interpretation limit of detection localized surface plasmon resonance (LSPR) magnitude nanoplasmonic immunoassay pandemic pathogenic inflammation Patient peptide Predictive profile Prognosis provide quantification Rapid SARS-CoV-2 serum serum cytokine Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [DOI] 10.1021/acsami.2c14748 PMC 바로가기
Effectiveness of the neutralizing antibody sotrovimab among high-risk patients with mild-to-moderate SARS-CoV-2 in QatarArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, [키워드] 95% confidence interval adjusted odds ratio Analysis BA.2 case-control study conducted Control control group controls COVID-19 COVID-19 severity Critical Disease progression drug Effectiveness eligible Epidemiology Evidence fatal COVID-19 food form high-risk patient higher risk incidence individual Mild-to-moderate neutralizing antibody occurred omicron Patient progression protective effect receive reducing SARS-CoV-2 Sotrovimab Sotrovimab. study period Subgroup analysis subgroup of patient Treatment treatment group United State [DOI] 10.1016/j.ijid.2022.09.023 PMC 바로가기
Computational pharmacology: New avenues for COVID-19 therapeutics search and better preparedness for future pandemic crisesArticle Published on 2022-11-012022-11-16 Journal: Biophysical chemistry [Category] 신약개발, [키워드] affected analysis approach Cheminformatics clinical clinical study clinical trials complex compounds COVID-19 COVID-19 pandemic COVID-19 therapeutics deep learning develop Disease progression drug Drug repurposing drugs effort global healthcare Health help identify in silico Infectious disease information Intervention lack limitation machine machine learning miRNA MONITOR New pandemic pharmacological strategy Regulatory Research robust Side-effects System Systems biology systems biology. targets therapeutic therapeutic target Treatment strategies [DOI] 10.1016/j.bpc.2022.106891 PMC 바로가기
Examining the impact of trimester of diagnosis on COVID-19 disease progression in pregnancyResearch article Published on 2022-11-012022-10-05 Journal: American journal of obstetrics & gynecology MFM [Category] 치료기술, [키워드] Affect Asymptomatic Blood COVID-19 diagnosis COVID-19 disease COVID-19 disease progression COVID-19 disease severity COVID-19 illness COVID-19 in pregnancy COVID-19 infection criteria Critical defined develop diagnosed with COVID-19 Diagnosis Disease progression evaluate the effect evaluated Examining Features Frequency had more Hispanic hospital Hospital admission Infection initially asymptomatic patient Maternal morbidity Mild mild infection Mild symptom moderate morbidity Neonatal Neonatal morbidity no significant difference not differ Older outcome outcomes pandemic Patient patients patients with asymptomatic Positive test Pregnancy pregnant patient pregnant patients progression prospective cohort study SARS-CoV-2 SARS-CoV-2 in pregnancy severity Stillbirth stratified symptomatic infection symptomatic patient Symptoms the timing trimester of infection Universal was performed [DOI] 10.1016/j.ajogmf.2022.100728 [Article Type] Research article
Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trialsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval addition anti-inflammatory effect antiparasitic antiviral activity blinded clinical benefit continuous variable COVID-19 D-dimer D-dimer level death dichotomous variable Disease progression Effect effect size Efficacy and safety element eligibility enrolled Evidence Frequency ICU admission in vitro individual Inflammation Invasive mechanical ventilation lactate dehydrogenase LDH magnitude Meta-analysis Mild moderate Moderate COVID-19 nitazoxanide no difference Patient patients peer-reviewed performed Placebo placebo-controlled positive positive RT-PCR Primary outcome randomized clinical trial RCT RCTs receiving reducing reduction in reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. secondary outcome serum biomarker SMD standardized mean difference systematic review tested to define treat treated Viral load WBC were used White blood cell with COVID-19 [DOI] 10.1007/s00228-022-03380-5 PMC 바로가기